Epidemiology and Impact of Disorders of Gut–Brain Interaction in Multiethnic Malaysia: An In-Depth Analysis of Local Data From the Rome Foundation Global Epidemiology Study

Journal

Journal of Gastroenterology and Hepatology (Australia)

Year

2025

Materials & Methods

2072 Malaysian participants from the Rome Foundation Global Epidemiology Study (RFGES) with complete data on DGBI were included in the in-depth analysis. We assessed the prevalence of DGBI diagnoses, psychological distress, QoL, healthcare utilization, dietary patterns, impact on sleep, work productivity, and activity impairment.

Results

The overall prevalence of any DGBI in Malaysia was 19.3% (95% CI 17.6%–21.0%). The top three most prevalent DGBI diagnoses were functional constipation (5.1%; 95% CI 4.2%–6.1%), functional dyspepsia (3.4%; 95% CI 2.7%–4.3%), and functional diarrhea (1.6%; 95% CI 1.1%–2.2%). Participants with DGBI reported higher levels of psychological distress (somatization, anxiety, and depression), significantly higher healthcare utilization, and dietary change (low FODMAPs but higher Mediterranean-based diet and probiotics). Furthermore, there was greater daytime sleepiness and higher proportions of presenteeism, overall work impairment, and activity impairment in individuals with DGBI.

Conclusion

The disease burden of DGBI is significant in Malaysia, with increased psychological distress, healthcare utilization, dietary change, greater daytime sleepiness, and greater overall work and activity impairment.

Resources and Links

Phone Number: +603 2781 4519 / +603 2781 4520

https://onlinelibrary.wiley.com/doi/10.1111/jgh.16953

Consultant Name

Dr Wong Zhiqin

[email protected]

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