Perioperative anaphylaxis in Malaysia: A nine-year retrospective study
Journal
Anaesthesia and Intensive Care
Year
2025
Conclusion
This study of POA in Malaysia found that skin tests were positive in almost all cases that had raised dynamic tryptase, and also in more than 70% of higher grades of POA—thus identifying the causative agent(s). NMBAs and antibiotics were the two most common causative agents of POA. Rocuronium and atracurium were the main agents responsible for NMBA anaphylaxis. The cross-reactivity rate among NMBAs was found to be 58%. Further, it could be estimated that the incidence of Grade 2–4 POA in Malaysia was approximately 1 in 30,000, although this may be an underestimate due to the voluntary nature of reporting, and the possibility that some milder Grade 2 cases of POA were underdiagnosed.
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https://journals.sagepub.com/doi/10.1177/0310057X241284655
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