Tepotinib Plus an EGFR Tyrosine Kinase Inhibitor in Patients With EGFR-Mutant MET-Altered NSCLC: A Case Series

Journal

Clinical Lung Cancer

Year

2025

Conclusion

This report highlights the unmet medical need of patients with advanced EGFR-mutant, MET-altered NSCLC in clinical practice, and supports the clinical benefit of tepotinib plus EGFR-TKIs in this setting, complementing clinical trial evidence.15,16,21 Given the heterogeneity of treatment resistance mechanisms in oncogene-driven advanced NSCLC and resultant challenge for trial enrollment, compassionate use programs may be increasingly important to enable patient access to novel therapies and generate evidence of therapeutic effectiveness.

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https://www.clinical-lung-cancer.com/article/S1525-7304(25)00043-9/fulltext

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Information

Consultant Name

Dr Tho Lye Mun

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