Research Publications

Regional anaesthesia is central to perioperative analgesia in foot and ankle surgery. Ultrasound-guided ankle and popliteal/saphenous nerve blocks are widely used, yet real-world evidence on their duration of action and factors associated with block failure is limited. This study aimed to document the duration of postoperative analgesia achieved with levobupivacaine ankle and popliteal/saphenous blocks and to explore contributors to failed or incomplete blocks.

Allergic rhinitis (AR) impacts quality of life, work and school productivity. Over the last years, an important body of evidence resulting from mHealth data has led to a better understanding of AR. Such advances have motivated an EAACI-endorsed update of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines (ARIA 2024–2025). This manuscript presents the ARIA 2024–2025 recommendations for intranasal treatments, one of the mainstays for AR management.

Dacomitinib, a second-generation, irreversible tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), showed statistically significant progression-free survival improvement over gefitinib in patients with treatment-naive EGFR mutation–positive advanced non-small cell lung cancer (NSCLC) in the phase 3 ARCHER 1050 study (NCT01774721). We report results from the final analysis of ARIA (NCT04609319), a noninterventional study of dacomitinib’s real-world utilization and associated clinical outcomes in Asian patients with EGFR mutation–positive advanced NSCLC.

Needs assessment tools may guide optimization of clinical services to be more patient-centered. As needs of patients living with and beyond colorectal cancer (CRC) may also be influenced by socio-cultural backgrounds and healthcare ecosystems, we developed and validated a needs assessment questionnaire for CRC in a multi-ethnic, low-and middle-income setting.

The perinatal period, from conception to one year postpartum, is a time of major physical and emotional change, with heightened risk for mental health disorders such as anxiety and depression—particularly in the Asia-Pacific region. Poor maternal mental health during this phase can lead to obstetric complications and adversely affect child development and neurodevelopment.

The relationship between myocardial injury after cardiac surgery (MICS), ischemia on electrocardiogram (ECG), and mortality is uncertain. In this study we aimed to determine whether potential ischemic ECG changes after cardiac surgery are associated with 30-day mortality.

Increasing prevalence of colorectal cancer (CRC) demands comprehensive understanding of the corresponding supportive care needs (SCN), especially in low and middle-income settings.